Epoetin trials: randomised controlled trials don't always mimic observational data

Epoetin trials: randomised controlled trials don't always mimic observational data.

The medical management of stage 3 and 4 chronic kidney disease (CKD) attempts to both slow the rate of progression towards dialysis and prevent the development of secondary complications associated with worsening uraemia. Clinicians attempt to achieve this by targeting blood pressure, lipids, calciumphosphate imbalance (mineral metabolism) and anaemia. Over the past 20 years, there has been a w...

Blindness in Randomized Controlled Trials

In combination with randomization, blinding or masking is an important factor in randomized controlled trials (RCTs), particularly in trials that assess therapeutic effects. Here an attempt is made to explain blindness and why it is important. In clinical trials, blinding is defined as the condition imposed on a study in which study participants, health care providers and assessors collecting o...

Introducing “Agreement on what to Measure in Randomised Controlled Trials in Burn Care” Research Project

پروژه پژوهشی "توافق درباره‌ی پیامدهای قابل اندازه‌گیری در کارآزمایی های کنترل‌دار مربوط به مراقبت‌های سوختگی" توسط گروهی از پژوهش‌گران با تجربه، در حوزه سوختگی، زیر نظر دکتر Young از کشور انگلستان در حال انجام می‌باشد. هدف نهایی از انجام این مطالعه، تهیه و تدوین مجموعه‌ای از پیامدهای اساسی (core outcome set (COS)) است که در گزارش کارآزمایی های شاهد‌دار تصادفی مربوط به مراقبت‌های سوختگی باید مور...

Randomised controlled trials.

Quality of randomised controlled trials

Editor—The Save European Science campaign (www.SaveEuropeanResearch.org) was launched on 9 December 2003 out of concern for the future of academic and investigator led research in Europe with the advent of the European Union clinical trials directive (see p 240). It was launched from a cancer platform but is inclusive in spirit and has already gained momentum in cardiology, dermatology, and psy...